The San Francisco 49ers have the distinction of being the first major league professional sports franchise on the West Coast. The 49ers entered professional football in 1946 and matured, nationally and locally, when the club was granted a National League franchise in 1950.

The team earned its name from the surge of goldminers to the San Francisco area during 1849, thus the nickname the San Francisco 49ers. It is the only name the team has been affiliated with and San Francisco is the only city in which it has resided.